… of gastric mucosal injury in patients taking low-dose aspirin in … pKa 3.5) and in the highly
acidic stomach (pH 1–2) it exists in … the platelet aggregation effect of clopidogrel [25,26], but at …

… of low-dose aspirin is associated with a high risk of gastric … and bicarbonates, and impairs
platelet aggregation; (ii) inhibition … aspirin and salicylic acid was >98 % under 120 min and pH …

… LDA therapy can also increase the risk of upper GI side effects, including acute mucosal
lesions, … Severe upper gastrointestinal bleeding with gastric ulcer and anaemia secondary to …

… from gastric mucosal injury11, 12 and plays an important role for … the gastrointestinal safety
of low-dose acetylsalicylic acid … in well-treated hypertensive patients, association of low-dose …

… and platelet aggregation and led to increased platelet inhibition … low dose of 50−75 mg daily
[8], which compromise clinical … platelets were lysed with ice-cold 100 mM Tris-HCl (PH 7.5) …

… may be useful for patients treated with low dose aspirin. … facilitated detailed examinations of
the entire digestive tract.(3–6) As … (9,10) Although the severity of mucosal injuries is milder in …

… infection or use of NSAIDs and low-dose aspirin (LDA), are the … , which occurs in association
with hospitalizations due to other … at pH 6.8, platelet aggregation reduces by >50% at pH 6.4 …

… Due to its inhibitory effect on platelet function, aspirin is … with low-dose aspirin was 40–80%
higher than in placebo-… Plain aspirin is absorbed in the stomach, where the low pH …

… LDA inhibits platelet aggregation by blocking COX-1, an isoform of … Association of gastric
mucosal injury severity with platelet function and gastric pH during low-dose aspirin treatment…

… gross area of macroscopic mucosal injury, severity grade of … Several clinical studies failed
to find any association between … , and subsequently acidified saline, at pH of 2 and a duration …